Fc-Free Single Chain Antibody mRNA Therapy for Airway Infection of Multidrug-Resistant Pseudomonas Aeruginosa
Mao Kinoshita, Ken Kawaguchi, Yuki Mochida, Nguyen Bui Thao Le, Atsushi Kainuma, Naoko Takeda-Miyata, Motohiro Kojima, Teiji Sawa, Satoshi Uchida
This study develops mRNA-based Fc-free scFv antibodies targeting Pseudomonas aeruginosa's type III secretion system, showing efficacy in treating multidrug-resistant airway infections in mice.
Nature Communications · Apr 9, 2026Peer-reviewedImmunology