SPATNIC is a variational autoencoder that identifies cancer cells from spatial and single-cell transcriptomic data in colorectal cancer, outperforming existing tools and identifying a rare cancer stem cell population.

bioRxiv · Oct 22, 2026 · PreprintCancer Biology

Single-cell spatial multiomics identifies POSTN+ CAFs mediating chemoradiotherapy resistance in rectal cancer

Shunsuke A. Sakai, Masayuki Okumura, Y Morinaga, Ken Kato, Motohiro Kojima, Falko Hofmann, Brian Reichholf, Pablo Augusto Vieyra-Garcia, Yuka Nakamura, Shingo Sakashita, Masaki Nakamura, Hidehiro Hojo, Yuichiro Tsukada, Masaaki Ito, Kohei Shitara, , Shun‐Ichiro Kageyama

The paper identifies POSTN-expressing cancer-associated fibroblasts (CAFs) linked to chemoradiotherapy resistance in rectal cancer using spatial multi-omics data.

bioRxiv · May 5, 2026 · PreprintCancer Biology

Fc-Free Single Chain Antibody mRNA Therapy for Airway Infection of Multidrug-Resistant Pseudomonas Aeruginosa

Mao Kinoshita, Ken Kawaguchi, Yuki Mochida, Nguyen Bui Thao Le, Atsushi Kainuma, Naoko Takeda-Miyata, Motohiro Kojima, Teiji Sawa, Satoshi Uchida

This study develops mRNA-based Fc-free scFv antibodies targeting Pseudomonas aeruginosa's type III secretion system, showing efficacy in treating multidrug-resistant airway infections in mice.

Nature Communications · Apr 9, 2026Peer-reviewedImmunology