Author

Yuki Mochida

Innovation Center of NanoMedicineORCID 0000-0002-5559-8519Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:multiome· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Satoshi UchidaiD· 2 shared Anjaneyulu DirisalaiD· 1 shared Atsushi KainumaiD· 1 shared Bhaskar ChatterjeeiD· 1 shared Jumpei NorimatsuiD· 1 shared Junichi Ishikawa· 1 shared Kazuko TohiD· 1 shared Kazunori KataokaiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBioengineering

Satoshi UchidaORCID

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2 papers

Recent·Most cited

2-arm-PEG-oligocations transiently shield the liver sinusoids to mitigate off-target hepatic expression of mRNA lipid nanoparticles

Anjaneyulu Dirisala, Bhaskar Chatterjee, Le Bui Thao Nguyen, Kazuko Toh, Miki Matsui-Masai, Saed Abbasi, Xueying Liu, Theofilus A. Tockary, Nan Qiao, Junichi Ishikawa, Jumpei Norimatsu, Yuki Mochida, Shigeto Fukushima, Makoto Oba, Kazunori Kataoka, Satoshi Uchida

This paper demonstrates that 2-arm-PEG-oligocations transiently shield liver sinusoids to reduce off-target hepatic mRNA expression and improve iLNP delivery to spleen and tumors.

ACS Nano · Aug 18, 2026Peer-reviewedBioengineering

Fc-Free Single Chain Antibody mRNA Therapy for Airway Infection of Multidrug-Resistant Pseudomonas Aeruginosa

Mao Kinoshita, Ken Kawaguchi, Yuki Mochida, Nguyen Bui Thao Le, Atsushi Kainuma, Naoko Takeda-Miyata, Motohiro Kojima, Teiji Sawa, Satoshi Uchida

This study develops mRNA-based Fc-free scFv antibodies targeting Pseudomonas aeruginosa's type III secretion system, showing efficacy in treating multidrug-resistant airway infections in mice.

Nature Communications · Apr 9, 2026Peer-reviewedImmunology