Tiam1-mediated synaptic plasticity drives comorbid depressive symptoms in chronic pain
Qin Ru, Yungang Lu, Ali Bin Saifullah, Francisco A. Blanco, Changqun Yao, Juan Pablo Cata, De‐Pei Li, Kimberley F. Tolias, Lingyong Li
This study identifies Tiam1-mediated synaptic plasticity in the ACC as a driver of depressive symptoms in chronic pain and shows that ketamine's antidepressant effects are mediated by blocking this pathway.
bioRxiv · Oct 15, 2021 · PreprintNeuroscience