NeurosciencebioRxivPreprint
Tiam1-mediated synaptic plasticity drives comorbid depressive symptoms in chronic pain
Qin Ru, Yungang Lu, Ali Bin Saifullah…·Lingyong Li
This study identifies Tiam1-mediated synaptic plasticity in the ACC as a driver of depressive symptoms in chronic pain and shows that ketamine's antidepressant effects are mediated by blocking this pathway.
DOI 10.1101/2021.10.15.464592