Yongjin Yoo

This study uses heterochronic myeloid cell replacement to show that the local brain environment, not intrinsic factors, drives microglia aging.

The paper develops human tri-lineage brain microtissues composed of neurons, astrocytes, and microglia, showing they recapitulate cell-cell interactions and pathological processes.

The paper identifies CD72 as a regulator of microglial tiling through proteomic profiling and functional assays.

This study shows oncogenic mutations disrupt lineage differentiation by altering DNA methylation, impairing stem cell reprogramming and differentiation while maintaining proliferation.

RAPIDASH enriches ribosome-associated proteins from diverse samples, revealing their roles in neurodevelopment and immune response.

This study identifies a neuroprotective myeloid state in MS and EAE models, showing that HCT enhances this state, leading to clinical improvement and reduced demyelination.

The paper identifies pathogenic variants in 57.5% of 553 undiagnosed neurodevelopmental patients, revealing a high proportion of recessive variants and their potential for carrier screening.

This study uses whole exome sequencing to diagnose 352 Korean pediatric patients with undiagnosed neurodevelopmental disorders, identifying pathogenic variants in 57.4% of cases.