Oliver Hahn

Heterochronic myeloid cell replacement reveals the local brain environment as key driver of microglia aging

This study uses heterochronic myeloid cell replacement to show that the local brain environment, not intrinsic factors, drives microglia aging.

Blockade of VCAM1 or VLA4 preserves cerebrovasculature and prevents cognitive decline late after stroke

This study shows that blocking VCAM1 or VLA4 after stroke preserves vascular integrity and prevents cognitive decline by promoting blood vessel growth and restoring the blood-brain barrier.

Gpr37 modulates the severity of inflammation-induced GI dysmotility by regulating enteric reactive gliosis.

This study identifies Gpr37 as a gene expressed in enteric glia cells of the myenteric plexus and shows its role in LPS-induced reactive gliosis and GI dysmotility.

Cell-surface proteomic profiling identifies CD72 as a regulator of microglial tiling

The paper identifies CD72 as a regulator of microglial tiling through proteomic profiling and functional assays.

A spatio-temporal brain miRNA expression atlas identifies sex-independent age-related microglial driven miR-155-5p increase

The paper creates a spatio-temporal miRNA atlas in mice, identifying age-related miR-155-5p increase driven by microglia, independent of sex.

Spatiotemporal transcriptomic niches of complement pathway and serine protease inhibitor activation in aging and infection

This study uses spatial transcriptomics to compare aging and infection effects across multiple organs in mice, identifying shared gene expression patterns in immune pathways.

Circulatory proteins shape microglia state and boost phagocytosis

The paper identifies a microglia population that takes up circulatory proteins, enhancing phagocytosis and innate immunity through ApoA-I uptake.

Augmentation of a neuroprotective myeloid state by hematopoietic cell transplantation

This study identifies a neuroprotective myeloid state in MS and EAE models, showing that HCT enhances this state, leading to clinical improvement and reduced demyelination.

Genetic Variants of Phospholipase C-γ 2 Confer Altered Microglial Phenotypes and Differential Risk for Alzheimers Disease

The paper identifies a PLCG2 variant, PLCG2M28L, associated with increased Alzheimer's disease risk and altered microglial phenotypes, while another variant, PLCG2P522R, reduces disease risk in a mouse model.

A spatiotemporal map of the aging mouse brain reveals white matter tracts as vulnerable foci

This study identifies molecular foci of brain aging in mice using spatiotemporal RNA-seq, showing accelerated glial aging in white matter and differential gene expression linked to neurodegenerative diseases.

Aging-associated changes in transcriptional elongation influence metazoan longevity.

This study identifies aging-associated increases in transcriptional elongation speed across multiple species and shows that reducing this speed extends lifespan.

Molecular hallmarks of heterochronic parabiosis at single cell resolution

This study uses single-cell RNA-sequencing to analyze cell type-specific responses to young or aged blood in heterochronic parabiosis, identifying mitochondrial function as a key factor in rejuvenation.

Broad transcriptional dysregulation of brain and choroid plexus cell types with COVID-19

The paper analyzes single-nucleus transcriptomes from brain and choroid plexus tissues of COVID-19 and influenza patients, identifying broad transcriptional dysregulation in multiple cell types and linking these changes to neurological symptoms.

Vesicle-bound regulatory RNAs are associated with tissue aging

The paper identifies aging-associated differences in vesicle-bound and freely circulating small regulatory RNAs in mice, showing tRNA fragments and miRNAs strongly correlate with aging.

Lipid droplet accumulating microglia represent a dysfunctional and pro-inflammatory state in the aging brain

The paper identifies lipid droplet-accumulating microglia (LAM) as a dysfunctional, pro-inflammatory state in aging brains, linked to neurodegeneration.

The murine transcriptome reveals global aging nodes with organ-specific phase and amplitude

The paper analyzes aging dynamics across 17 organs and plasma proteomics in mice, revealing consistent gene expression trajectories with organ-specific timing and amplitude.