Maria Barna

Human organoid screen links transient translational modulation to progenitor progression in corticogenesis

The paper screens human cortical organoids with small molecules to identify translational modulators affecting progenitor progression in corticogenesis, finding Emetine promotes neuronal differentiation.

Ribosomal DNA copy number variation shapes human physiology and disease risk

The paper analyzes rDNA copy number variation in humans, finding distinct associations with metabolic diseases and growth traits.

Ribosome heterogeneity arising from common and rare rRNA sequence variants affects diverse human phenotypes

The paper identifies rRNA sequence variants affecting human traits and diseases by analyzing UK Biobank data and developing the RiboVAn method.

RAPIDASH: A tag-free enrichment of ribosome-associated proteins reveals compositional dynamics in embryonic tissues and stimulated macrophages

RAPIDASH enriches ribosome-associated proteins from diverse samples, revealing their roles in neurodevelopment and immune response.

Diversity of ribosomes at the level of rRNA variation associated with human health and disease

This study identifies and characterizes rRNA variants in human tissues and cancer, revealing tissue-specific ribosome subtypes and cancer-specific ribosome variations.

Subfunctionalized expression drives evolutionary retention of ribosomal protein paralogs in vertebrates

The paper investigates the evolutionary retention of ribosomal protein paralogs eS27 and eS27L by showing their subfunctionalized expression patterns are necessary for maintaining total protein expression across cell types.

Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics

This study develops PERSIST-seq and In-line-seq to optimize mRNA stability and translation, finding that in-cell stability is more critical than ribosome load for protein output.

Evolutionarily divergent mTOR remodels the translatome to drive rapid wound closure and regeneration

This study identifies mTOR-mediated translational activation as a key mechanism for rapid wound closure and regeneration in axolotls, distinct from non-regenerative mammals.

A p53-dependent translational program directs tissue-selective phenotypes in a model of ribosomopathies

This study identifies a p53-dependent translational program that explains tissue-selective phenotypes in ribosomopathies by regulating 4E-BP1 and altering the translatome.

Functional and structural basis of extreme non-coding conservation in vertebrate 5'UTRs

The paper identifies conserved 5'UTRs as regulators of translation and reveals their structural dynamics using a new method.