Hao Li

PPARgene 2.0: leveraging large language models and multi-omics data for enhanced identification and prediction of PPAR target genes

PPARgene 2.0 updates the database with new PPAR target genes and improves prediction using language models and ChIP-seq data.

Deletion of sulfate transporter SUL1 extends yeast replicative lifespan via reduced PKA signaling instead of decreased sulfate uptake

This study shows that deleting SUL1 in yeast extends replicative lifespan through reduced PKA signaling, not by decreasing sulfate uptake.

Yeast replicative aging leads to permanent cell cycle arrest in G1 effectuated by the start repressor Whi5

This study shows that yeast replicative aging causes permanent G1 cell cycle arrest mediated by the Whi5 repressor, with increased Whi5 concentration correlating with G1 lengthening and cell death.