A Human Hippocampal Organoid Model with Sustained Neural Stem Cells Reveals State Shifts Under Glucocorticoid Stress
Olivia Soper, Muhammad Zaman Khan Assir, Delia Ramírez, Gabriella Crawford, Richard Gyuris, Sara S. M. Valkila, Laetitia L. Lecante, Peng Liu, Paul Fowler, J. Antonio González, Daniel A. Berg, Eunchai Kang
This study develops a human hippocampal organoid model that shows how glucocorticoid stress shifts neural stem cell states, reducing proliferation and promoting quiescence.
bioRxiv · Nov 3, 2025 · PreprintNeuroscience