Eunchai Kang

This study shows that chronic genotoxic and metabolic stress induce distinct yet overlapping senescence programs in human microglia, characterized by morphological changes, mitochondrial remodelling, and inflammatory activation.

This study establishes a human in vitro model of DNA damage-induced senescence in neural progenitor cells and identifies senescence-associated transcriptomic and functional changes linked to hippocampal ageing and neurodegeneration.

Scarecrow improves data recovery from single-cell combinatorial barcoding by accounting for positional errors in barcode sequences, enhancing downstream analyses.

This study develops a human hippocampal organoid model that shows how glucocorticoid stress shifts neural stem cell states, reducing proliferation and promoting quiescence.

The paper shows IL-17A disrupts human cortical development in a 3D ex vivo model of maternal immune activation by altering neurogenesis and ECM pathways.