Revolutionizing GPCR-Ligand Predictions: DeepGPCR with experimental Validation for High-Precision Drug Discovery
Haiping Zhang, Hongjie Fan, Jixia Wang, Tao Hou, Konda Mani Saravanan, Wei Xia, Hei Wun Kan, Junxin Li, John Z. H. Zhang, Xinmiao Liang, Yang Chen
The paper develops two GPCR-specific models, DeepGPCR_BC and DeepGPCR_RG, for binary classification and affinity prediction of ligand interactions, achieving better performance than existing tools.
Briefings in Bioinformatics · May 23, 2024Peer-reviewedBioinformatics