Hongjie Fan

This study shows that lethal Streptococcus suis serotype 2 infection in mice is driven by widened lymph node bottlenecks and the virulence factor suilysin, leading to systemic bacterial spread.

The paper develops two GPCR-specific models, DeepGPCR_BC and DeepGPCR_RG, for binary classification and affinity prediction of ligand interactions, achieving better performance than existing tools.