Molecular BiologyMolecular MetabolismPeer-reviewed
Molecular interactions of PCSK9 with an inhibitory nanobody, CAP1 and HLA-C: functional regulation of LDLR levels
Carole Fruchart‐Gaillard, Ali Ben Djoudi Ouadda, Lidia Ciccone…·Nabil Georges Seidah
This study determines the 3D structure of the PCSK9-CHRD-P1.40 complex and shows how CAP1 and HLA-C interact with PCSK9 to regulate LDLR degradation.
22 citations