Microglial GSDMD-Mediated Pyroptosis Drives Neuroinflammation in Parkinson's Disease
Mengmeng Wang, Yuedong Wang, Tianyi Wang, Yi Han, Tao Huang, Jicong Du, You Yin
This study shows that microglial pyroptosis via the CASPASE-1/GSDMD pathway drives neuroinflammation and dopaminergic neuron loss in Parkinson's disease, suggesting GSDMD as a therapeutic target.
bioRxiv · Jun 30, 2025 · PreprintNeuroscience