Tao Huang

This study shows that microglial pyroptosis via the CASPASE-1/GSDMD pathway drives neuroinflammation and dopaminergic neuron loss in Parkinson's disease, suggesting GSDMD as a therapeutic target.

This paper introduces two novel MR methods for binary outcomes that address pleiotropy and improve statistical power and reduce false positives.

This study uses Mendelian randomization to assess the causal effects of risk factors and drug targets on lacunar stroke, identifying potential drug repurposing opportunities.

This study examines how sleep quality affects biological aging and its interaction with air pollution using UK Biobank data, finding sleep improves aging outcomes and mitigates pollution effects.

This study identifies 242 genetic loci for glycaemic traits using trans-ancestry meta-analysis, finding 99 novel loci and improved fine-mapping resolution compared to single-ancestry analyses.