Neil Dalchau

Intein-assisted bisection mapping systematically splits proteins for Boolean logic and inducibility engineering

This paper introduces IBM, a method that systematically splits proteins into logic gates using inteins, enabling inducible control of protein function.

Scalable dynamic characterization of synthetic gene circuits

This paper presents a method to dynamically characterize synthetic gene circuits using time-series data and parameter inference, enabling scalable analysis of complex circuits in E. coli.

Distributed DNA-based Communication in Populations of Synthetic Protocells

This paper introduces a platform for distributed DNA-based communication in synthetic protocells using DNA strand-displacement circuits.

A theory for how the antigen presentation profile influences the timing of T-cell detection

The paper models how optimal peptide filtering by antigen-presenting cells affects the timing of T-cell detection, finding an optimal filtering range influenced by MHC properties.

Model reduction permits Turing instability analysis of arbitrary reaction-diffusion models

This paper introduces a method to reduce complex biochemical systems to simpler ones for Turing instability analysis, demonstrating its effectiveness with examples.

A Spatially Localized Architecture for Fast and Modular Computation at the Molecular Scale

The paper demonstrates spatially localized DNA circuits that enable fast and modular molecular computation by arranging reactive DNA hairpins on DNA origami.