Stephen Mann

DIALECT enables synthetic cells to communicate with mammalian cells via DNA-programmed ligand release and engineered receptors, achieving specific signaling and logic gate functions.

The paper develops hybrid 3D cancer cultures using synthetic and natural cells to mimic tumor immune microenvironments and identify immune evasion mechanisms.

This paper develops thermoresponsive microcapsules for repeated random access of DNA data, demonstrating improved performance over non-compartmentalized storage.

The paper develops DNA-encoded sender-receiver architectures using microfluidic trapping arrays and light-activated DNA strand displacement to study diffusion-based signaling and spatial integration of chemical communication.

This paper introduces a platform for distributed DNA-based communication in synthetic protocells using DNA strand-displacement circuits.