Yu Zhang

The paper identifies B4GALT1 as a regulator of CD8+ T-cell function through N-glycosylation, showing its potential as a target for immunotherapy.

This study compares dimensionality reduction methods for bulk transcriptomic data, finding UMAP better preserves sample neighbourhood and clustering accuracy than PCA, MDS, and t-SNE.

QUBIC2 improves biclustering for bulk and single-cell RNA-Seq by addressing sparsity and transcriptional regulation, outperforming existing tools in functional module detection and cell type classification.