Evolutionary BiologyQuantitative BiologyPeer-reviewed
Modeling Combination Chemo-Immunotherapy for Heterogeneous Tumors
Shaoqing Chen, Zheng Hu, Da Zhou
This study develops mathematical models to explore how chemotherapy and immune checkpoint blockade (ICB) combination therapy affects heterogeneous tumors, revealing chemotherapy's role in reducing antigenic heterogeneity and enhancing ICB efficacy through immune recovery.