Conformational switch of a peptide provides a novel strategy to design peptide loaded porous organic polymer for Pyroptosis pathway mediated cancer therapy
Snehasis Mishra, Achinta Sannigrahi, Santu Ruidas, Sujan Chatterjee, Kamalesh Roy, Deblina Misra, Barun Kumar Maity, Rabindranath Paul, Chandan Kumar Ghosh, Krishna Das Saha, Asim Bhaumik, Krishnananda Chattopadhyay
This paper designs a peptide-loaded porous organic polymer that undergoes a conformational switch in cancer cells, triggering pyroptosis via membrane pore formation.
Small · Jun 24, 2024Peer-reviewedBiochemistry