Hormone-induced enhancer assembly requires an optimal level of hormone receptor multivalent interactions
Lizhen Chen, Zhao Zhang, Qinyu Han, Barun Kumar Maity, Leticia Rodrigues, Emily Kate Zboril, Rashmi Adhikari, Su Hyuk Ko, Xin Li, Shawn R. Yoshida, Pengya Xue, Emilie Smith, Kexin Xu, Qianben Wang, Tim H.‐M. Huang, , Zhijie Liu
This study shows that optimal AR NTD multivalent interactions are required for enhancer assembly and transcriptional activity, with excessive condensation impairing function and potentially contributing to disease.
Molecular Cell · Sep 21, 2023Peer-reviewedMolecular Biology