Cell BiologybioRxivPreprint
BMP9-mediated regulation of endothelin-1 requires integrated SMAD1/5 and SMAD2/3 signaling
Jana Bagarova, Shreya Sangam, Luca Troncone…·Paul B. Yu
This study shows BMP9 regulates ET-1 through coordinated SMAD1/5 and SMAD2/3 signaling in endothelial cells, revealing a non-canonical mechanism relevant to pulmonary arterial hypertension.