BMP9-mediated regulation of endothelin-1 requires integrated SMAD1/5 and SMAD2/3 signaling
Jana Bagarova, Shreya Sangam, Luca Troncone, Ying Zhong, Lillian R. Worst, Gregory R. Gipson, Ivana Nikolić, Samuel D Paskin-Flerlage, S. Paul Oh, Fernando Rodríguez‐Pascual, Paul B. Yu
This study shows BMP9 regulates ET-1 through coordinated SMAD1/5 and SMAD2/3 signaling in endothelial cells, revealing a non-canonical mechanism relevant to pulmonary arterial hypertension.
bioRxiv · Dec 26, 2025 · PreprintCell Biology