Paul B. Yu

This study identifies age- and disease-specific remodeling of cardiac lymphatic endothelial cells through single-nucleus transcriptomics and spatial analysis.

This study shows BMP9 regulates ET-1 through coordinated SMAD1/5 and SMAD2/3 signaling in endothelial cells, revealing a non-canonical mechanism relevant to pulmonary arterial hypertension.

This study shows that inhibiting BMP9 signaling reduces endothelial secretion of vasoactive factors that drive pulmonary vascular remodeling in pulmonary hypertension.

The paper integrates cross-species single-cell data from rodent PH models and human disease to identify overlapping cell subsets and novel macrophage and endothelial subtypes involved in PH.

The paper identifies saracatinib as a potent ALK2 inhibitor effective in preventing heterotopic ossification in FOP models.