Author

Shannon Laub

University of PennsylvaniaORCID 0000-0002-4917-5042Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Assay:ATAC-seq· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Alessandra ChesiiD· 2 shared Natalia M. TulinaiD· 2 shared Aura María RamíreziD· 1 shared Bao Khanh TrangiD· 1 shared Emily Greenfest‐AlleniD· 1 shared Fulai JiniD· 1 shared Gao T. WangiD· 1 shared Gerard D. SchellenbergiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersGenetics

Alessandra ChesiORCID

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2 papers

Recent·Most cited

GeneticsThe American Journal of Human GeneticsPeer-reviewedMay 26, 2026

Integration of Alzheimer's GWAS, 3D genomics, and single-cell CRISPRi non-coding screen implicates causal variants in a microglial enhancer regulating TSPAN14.

Shannon Laub, Natalia M. Tulina, Matthew Hoffman…·Alessandra Chesi

1 citation

humanGWAS summary statistics

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Genetic & Genomic Medicinenpj DementiaPeer-reviewedDec 16, 2025

Integrated genomic analysis and CRISPRi implicates EGFR in Alzheimer's disease risk

Yuk Yee Leung, Pavel P. Kuksa, Luke Carter…·Li‐San Wang

The paper identifies EGFR as a potential therapeutic target in Alzheimer's disease by linking a risk variant to increased EGFR expression in brain cell types through genomic analysis and CRISPRi validation.

3 citations

humanbulk RNA-seq

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