Author

Natalia M. Tulina

University of PennsylvaniaORCID 0000-0002-1997-4521Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Assay:ATAC-seq· 2 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:CRISPR screen· 1

Frequent Co-Authors

Alessandra ChesiiD· 2 shared Shannon LaubiD· 2 shared Ana G. CristanchoiD· 1 shared Aura María RamíreziD· 1 shared Bao Khanh TrangiD· 1 shared Emily Greenfest‐AlleniD· 1 shared Fulai JiniD· 1 shared Gao T. WangiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersGenetics

Alessandra ChesiORCID

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3 papers

Recent·Most cited

Integration of Alzheimer's GWAS, 3D genomics, and single-cell CRISPRi non-coding screen implicates causal variants in a microglial enhancer regulating TSPAN14.

Shannon Laub, Natalia M. Tulina, Matthew Hoffman, Joe Faryean, Sandhya Ramachandran, Bao Khanh Trang, Stephanie M. Lewkiewicz, Alessandra Chesi

The American Journal of Human Genetics · May 26, 2026Peer-reviewedGenetics

Integrated genomic analysis and CRISPRi implicates EGFR in Alzheimer's disease risk

Yuk Yee Leung, Pavel P. Kuksa, Luke Carter, Jeffrey Cifello, Emily Greenfest‐Allen, Otto Valladares, Louisa Boateng, Shannon Laub, Natalia M. Tulina, Sofia Moura, Aura María Ramírez, Katrina Celis, Fulai Jin, Ru Feng, Gao T. Wang, , Li‐San Wang

The paper identifies EGFR as a potential therapeutic target in Alzheimer's disease by linking a risk variant to increased EGFR expression in brain cell types through genomic analysis and CRISPRi validation.

npj Dementia · Dec 16, 2025Peer-reviewedGenetic & Genomic Medicine

Intrauterine inflammation leads to some sex and age-specific behavior and molecular differences in mice

Ana G. Cristancho, Natalia M. Tulina, Lauren Anton, Guillermo Barila, Michal A. Elovitz

This study investigates age and sex-specific behavioral and molecular effects of prenatal inflammation in mice, finding male-specific anxiety increases in adults and sex-specific neurogenesis gene expression changes.

bioRxiv · Apr 24, 2022 · PreprintDevelopmental Biology