Paul G. Feinstein

This study uses a transgenic approach to increase OR expression in OSNs and links OR10G4 activation to specific odor qualities through ligand screening.

The paper shows that the Olfr151 odorant receptor promoter is inactive in mouse embryonic stem cells despite exposure to epigenetic modulators and potential activators.

The paper examines how different SARS-CoV-2 variants bind to the human ACE2 receptor, identifying regions of ACE2 involved in binding and suggesting multiple binding sites contribute to interaction.

The paper investigates the interaction between SARS-CoV-2 spike RBD and membrane-bound ACE2, showing rapid internalization and ACE2 downregulation, with variant-specific differences in binding dependencies.

The paper describes an ex vivo platform using olfactory cilia to functionally profile human odorant receptors with high sensitivity and scalability.

The paper demonstrates that E. coli can cotransform multiple plasmids, leading to non-clonal colonies and revealing complex colony development patterns.

The paper identifies a common mechanism for singular gene expression in odorant receptors by analyzing transgenic mice with enhanced OR1A1 expression.

This study investigates ingestive behavior deficits in Prrxl1 knockout mice, revealing impaired trigeminal pathway function and its impact on orosensory processing across multiple timescales.

The paper identifies trimethylamine as a male-specific odor detected via TAAR5 in the main olfactory pathway that drives inter-male aggression in mice, independent of glomerular input.

The paper identifies TRPM5-expressing microvillous cells in the olfactory epithelium as potentially involved in viral infection through transcriptional profiling.

The paper analyzes single-cell sperm RNA-seq data from fathers of autistic and healthy children to identify mutation clusters and expression differences associated with ASD risk.

The paper shows that single olfactory receptors, specifically TAARs, set odor detection thresholds in mice, with sensitivity determined by the most sensitive receptor.