Diego Restrepo

Opto2P-FCM: A MEMS based miniature two-photon microscope with two-photon patterned optogenetic stimulation

This paper introduces a miniature two-photon microscope with optogenetic stimulation for studying neural activity in freely moving mice.

Multi-site temporal control of optogenetic stimulation enhances firing frequencies in peripheral nerves

This study shows that multi-site optogenetic stimulation can increase firing rates in peripheral nerves through in silico, ex vivo, and in vivo experiments.

Intranasal HSV 1 Infection Drives Region Specific Interferon Dominant Microglial Remodeling

This study investigates how HSV-1 infection remodels microglial transcriptional and epigenetic states, revealing IFN-responsive dominance and loss of homeostatic signatures in specific brain regions.

Voltage Imaging with Periodic Structured Illumination

This paper demonstrates reduced signal contamination from out-of-focus cells in vivo voltage imaging using pHiLo compared to traditional widefield methods in awake mice.

Miniaturized widefield microscope for high speed voltage imaging

The paper presents a miniaturized widefield microscope for high-speed voltage imaging in freely moving animals, achieving a peak-to-noise ratio >3 at 530 Hz.

Connexin 36-mediated gap junctions contribute to fine odor discrimination and excitation of mitral cells in the mouse olfactory bulb

This study shows that Cx36 gap junctions in the mouse olfactory bulb are important for fine odor discrimination and late excitation of mitral cells.

Airway succinate chemosensing induces CFTR-dependent anion secretion and mucus clearance which is impaired in cystic fibrosis.

Olfactory and Trigeminal Routes of HSV-1 CNS Infection with Regional Microglial Heterogeneity

This study tracks HSV-1 spread from the nasal passages to the CNS in mice, revealing region-specific infection patterns and microglial responses.

Miniscope Recording Calcium Signals at Hippocampus of Mice Navigating an Odor Plume

The paper describes a protocol to monitor mouse behavior and record calcium signals in hippocampal neurons during odor plume navigation, including surgery, imaging, data processing, and decoding of spatial paths.

Long-term in vivo three-photon imaging reveals region-specific differences in healthy and regenerative oligodendrogenesis

This study uses three-photon imaging to show that white matter generates more oligodendrocytes than gray matter, but gray matter shows faster growth rates and regenerative deficits after injury.

Decision-Making Time Cells in Hippocampal Dorsal CA1

The paper identifies decision-making time cells in dorsal CA1 pyramidal neurons during associative learning in mice, showing sequential activity encodes temporal memory for decision-making.

GRINtrode: A neural implant for simultaneous two-photon imaging and extracellular electrophysiology in freely moving animals

This paper introduces a neural implant that enables simultaneous two-photon imaging and extracellular electrophysiology in freely moving animals, showing a positive correlation between optical and electrical recordings.

Hippocampal-prefrontal theta coupling develops as mice become proficient in associative odorant discrimination learning

The paper examines how theta-phase referenced power (tPRP) and theta-referenced phase-amplitude coupling (tPAC) change in mice during odorant discrimination learning, showing increased decoding accuracy and reduced coordination in the absence of CaMKII.

Signatures for Viral Infection and Inflammation in the Proximal Olfactory System in Familial Alzheimer's Disease

The paper identifies viral infection and inflammation signatures in the olfactory system of familial Alzheimer's disease patients, suggesting their role in disease progression.

Characterization of red fluorescent reporters for dual-color in vivo three-photon microscopy

The paper evaluates tdTomato and mScarlet fluorescent proteins for dual-color three-photon microscopy in the mouse brain, finding high signal-to-background in specific wavelength ranges.

Excitable axonal domains adapt to sensory deprivation in the olfactory system

This study shows that unilateral sensory deprivation leads to system-wide adaptations in mitral cell axons and physiology in the olfactory system.

Transcriptional profiling reveals potential involvement of microvillous TRPM5-expressing cells in viral infection of the olfactory epithelium

The paper identifies TRPM5-expressing microvillous cells in the olfactory epithelium as potentially involved in viral infection through transcriptional profiling.

Molecular layer interneurons in the cerebellum encode for valence in associative learning

The paper shows that cerebellar molecular layer interneurons encode valence during associative learning in mice.

Hyperexcitability and loss of feedforward inhibition in the Fmr1KO lateral amygdala.

This study shows that Fmr1KO mice have hyperexcitability and increased excitatory synaptic strength in the lateral amygdala, with reduced feedforward inhibition contributing to enhanced plasticity and E/I imbalance linked to anxiety disorders.

Learning improves decoding of odor identity with phase-referenced oscillations in the olfactory bulb

Cell type specific control of basolateral amygdala plasticity via entorhinal cortex-driven feedforward inhibition

The paper identifies a subpopulation of fast-spiking Sst+ interneurons that mediate feedforward inhibition and gate plasticity in the basolateral amygdala.

Differential Expression of Mucins in Murine Olfactory Versus Respiratory Epithelium

The paper examines mucin expression differences between olfactory and respiratory epithelium in mice and finds no radiation-induced changes in mucin expression after 8 Gy exposure.

Homeostatic Inhibitory Control of Cortical Hyperexcitability in Fragile X Syndrome

This study shows that in FXS mouse models, hyperexcitability leads to impaired inhibitory synaptic plasticity and altered mGluR function in the somatosensory cortex.

Three dimensional two-photon imaging of neuronal activity in freely moving mice using a miniature fiber coupled microscope with active axial-scanning

This paper introduces a miniature two-photon microscope for 3D neuronal imaging in freely moving mice, demonstrating active axial scanning and multi-color fluorescence imaging.