Author

Laëtitia Merle

University of Colorado Anschutz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Assay:electronic health records· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Arianna Gentile Polese· 4 shared Diego RestrepoiD· 4 shared Andrew N. BubakiD· 3 shared B. Dnate’ Baxter· 3 shared Christy S. NiemeyeriD· 3 shared Maria A. NageliD· 3 shared James E. HasselliD· 2 shared Vijay R. RamakrishnaniD· 2 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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4 shared papersNeuroscience

Arianna Gentile Polese

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

SARS-CoV-2 Delta variant induces severe damages in the nasal cavity from the first day post-infection in the Syrian hamster model.

Maxime Fusade-Boyer, Adèle Gambino, Laëtitia Merle, Audrey Saint-Albin, Ophélie Grard, Juliette Jacquelin, Younes Boujedli, Hélène Huet, Meriadeg Ar Gouilh, Sandra Martin‐Latil, Bernard Klonjkowski, Nicolas Meunier, Sophie Le Poder

This study compares early nasal cavity damage caused by SARS-CoV-2 D614G, Delta, and Omicron variants in Syrian hamsters, finding Delta causes more rapid viral spread and damage at 1 dpi.

Virulence · Jun 30, 2025Peer-reviewedMicrobiology

Olfactory and Trigeminal Routes of HSV-1 CNS Infection with Regional Microglial Heterogeneity

Christy S. Niemeyer, Laëtitia Merle, Andrew N. Bubak, B. Dnate’ Baxter, Arianna Gentile Polese, Katherine Colon-Reyes, Sandy Vang, James E. Hassell, Kimberley D. Bruce, Maria A. Nagel, Diego Restrepo

This study tracks HSV-1 spread from the nasal passages to the CNS in mice, revealing region-specific infection patterns and microglial responses.

Journal of Virology · Oct 30, 2024Peer-reviewedNeuroscience

Signatures for Viral Infection and Inflammation in the Proximal Olfactory System in Familial Alzheimer's Disease

Andrew N. Bubak, Laëtitia Merle, Christy S. Niemeyer, B. Dnate’ Baxter, Arianna Gentile Polese, Vijay R. Ramakrishnan, Johana Gómez, Lucía Madrigal, Andrés Villegas‐Lanau, Francisco Javier Lopera, Wendy B. Macklin, Seth E. Frietze, Maria A. Nagel, Diego Restrepo

The paper identifies viral infection and inflammation signatures in the olfactory system of familial Alzheimer's disease patients, suggesting their role in disease progression.

bioRxiv · Jul 19, 2022Neuroscience

Excitable axonal domains adapt to sensory deprivation in the olfactory system

Nicholas M. George, Arianna Gentile Polese, Laëtitia Merle, Wendy B. Macklin, Diego Restrepo

This study shows that unilateral sensory deprivation leads to system-wide adaptations in mitral cell axons and physiology in the olfactory system.

Journal of Neuroscience · Jan 12, 2022Peer-reviewedNeuroscience

Transcriptional profiling reveals potential involvement of microvillous TRPM5-expressing cells in viral infection of the olfactory epithelium

B. Dnate’ Baxter, Eric D. Larson, Laëtitia Merle, Paul G. Feinstein, Arianna Gentile Polese, Andrew N. Bubak, Christy S. Niemeyer, James E. Hassell, Doug P. Shepherd, Vijay R. Ramakrishnan, Maria A. Nagel, Diego Restrepo

The paper identifies TRPM5-expressing microvillous cells in the olfactory epithelium as potentially involved in viral infection through transcriptional profiling.

BMC Genomics · Mar 29, 2021Peer-reviewedNeuroscience