Developmental BiologyDevelopmentPeer-reviewed
Mesenchymal-Epithelial Transition Regulates Initiation of Pluripotency Exit before Gastrulation
Sofiane Hamidi, Yukiko Nakaya, Hiroki Nagai…·Guojun Sheng
The paper shows that pluripotent stem cells undergo a mesenchymal-epithelial transition (MET) before losing pluripotency, which is distinct from the gastrulation EMT and regulated by integrin-mediated cell-matrix interactions.
30 citations