Author

Hitoshi Niwa

Kumamoto UniversityORCID 0000-0002-5280-8031Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Hitoshi Niwa2 papers · The University of Osaka

Biology Disciplines

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Developmental Biology· 4

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Assay:ChIP-seq· 1

Frequent Co-Authors

Kei‐ichiro IshiguroiD· 2 shared Kimi ArakiiD· 2 shared Naoki TaniiD· 2 shared Ryuki ShimadaiD· 2 shared Sayoko Fujimura· 2 shared Shingo UsukiiD· 2 shared Aeju LeeiD· 1 shared Akihiko SakashitaiD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersDevelopmental Biology

Kei‐ichiro IshiguroORCID

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4 papers

Recent·Most cited

MEIOSIN retains an intrinsic STRA8-independent activity that drives meiotic entry across vertebrate evolution

Ryuki Shimada, Yukiko Imai, Kimi Araki, Toshihiro Kawasaki, Sakie Iisaka, Shingo Usuki, Kei-ichiro Yasunaga, Sayoko Fujimura, Naoki Tani, Hitoshi Niwa, Shigehiro Kuraku, Noriyoshi Sakai, Kei‐ichiro Ishiguro

The paper shows MEIOSIN has a STRA8-independent activity that drives meiotic entry in vertebrates, with different effects in zebrafish and mice.

bioRxiv · Mar 6, 2026 · PreprintDevelopmental Biology

Inhibition of N-myristoyltransferase Promotes Naive Pluripotency in Mouse and Human Pluripotent Stem Cells

Junko Yoshida, Hitomi Watanabe, Kaori Yamauchi, Takumi Nishikubo, Ayako Isotani, Satoshi Ohtsuka, Hitoshi Niwa, Hidenori Akutsu, Akihiro Umezawa, Hirofumi Suemori, Yasuhiro Takashima, Gen Kondoh, Junji Takeda, Kyoji Horie

This study shows that inhibiting N-myristoyltransferase (Nmt) promotes naive pluripotency in both mouse and human pluripotent stem cells.

bioRxiv · Jun 22, 2021 · PreprintDevelopmental Biology

Meiosis-specific ZFP541 repressor complex promotes meiotic prophase exit during spermatogenesis

Yuki Takada-Horisawa, Chisato Kodera, Kazumasa Takemoto, Akihiko Sakashita, Kenichi Horisawa, Ryo Maeda, Shingo Usuki, Sayoko Fujimura, Naoki Tani, Kumi Matsuura, Ryuki Shimada, Tomohiko Akiyama, Atsushi Suzuki, Hitoshi Niwa, Makoto Tachibana, , Kei‐ichiro Ishiguro

This study identifies a ZFP541-KCTD19 repressor complex that promotes meiotic prophase exit in spermatogenesis by suppressing transcriptional regulators and chromatin modifiers.

bioRxiv · Jan 15, 2021 · PreprintDevelopmental Biology

Mesenchymal-Epithelial Transition Regulates Initiation of Pluripotency Exit before Gastrulation

Sofiane Hamidi, Yukiko Nakaya, Hiroki Nagai, Cantas Alev, Takeya Kasukawa, Sapna Chhabra, Aeju Lee, Hitoshi Niwa, Aryeh Warmflash, Tatsuo Shibata, Guojun Sheng

The paper shows that pluripotent stem cells undergo a mesenchymal-epithelial transition (MET) before losing pluripotency, which is distinct from the gastrulation EMT and regulated by integrin-mediated cell-matrix interactions.

Development · Feb 1, 2020Peer-reviewedDevelopmental Biology