Mesenchymal-Epithelial Transition Regulates Initiation of Pluripotency Exit before Gastrulation
Sofiane Hamidi, Yukiko Nakaya, Hiroki Nagai, Cantas Alev, Takeya Kasukawa, Sapna Chhabra, Aeju Lee, Hitoshi Niwa, Aryeh Warmflash, Tatsuo Shibata, Guojun Sheng
The paper shows that pluripotent stem cells undergo a mesenchymal-epithelial transition (MET) before losing pluripotency, which is distinct from the gastrulation EMT and regulated by integrin-mediated cell-matrix interactions.
Development · Feb 1, 2020Peer-reviewedDevelopmental Biology