The Kv2.2 channel mediates the inhibition of Prostaglandin E2 on glucose-stimulated insulin secretion in pancreatic β-cells
Chengfang Pan, Ying Liu, Liangya Wang, Wen-Yong Fan, Yunzhi Ni, Xuefeng Zhang, Di Wu, Chenyang Li, Jin Li, Zhaoyang Li, Rui Liu, Changlong Hu
This study shows PGE2 inhibits glucose-stimulated insulin secretion in β-cells via the EP2/4-Kv2.2 pathway by modulating Kv2.2 channels through PKA.
eLife · Jun 21, 2024Peer-reviewedPhysiology