The epigenetic evolution of gliomas is determined by their IDH1 mutation status and treatment regimen
Tathiane Maistro Malta, Thaís S. Sabedot, Natalia S. Morosini…·Peter S. LaViolette
This study analyzes the epigenetic evolution of IDH1-mutant and IDH1-wildtype gliomas under treatment, showing IDHmut tumors undergo epigenomic changes resembling IDHwt tumors, with implications for treatment strategies.