Author

Natalia S. Morosini

Henry Ford HealthORCID 0000-0002-9294-9461Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Assay:scATAC-seq· 1

Frequent Co-Authors

Ana C. deCarvalhoiD· 2 shared Ana Valeria CastroiD· 2 shared Anna LasorellaiD· 2 shared Antonio IavaroneiD· 2 shared Houtan NoushmehriD· 2 shared Luciano GarofanoiD· 2 shared Adelheid WöehreriD· 1 shared Allison K Lowman· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersCancer Biology

Ana C. deCarvalhoORCID

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2 papers

Recent·Most cited

Single-nucleus multiomics unveils malignant cellular states, regulatory architectures and microenvironmental reorganization across the G-CIMP epigenomic transition in IDH-mutant glioma

Grayson A. Herrgott, Luciano Garofano, Natalia S. Morosini, Bogdan Done, Christopher Powell, Ana C. deCarvalho, Laura A. Hasselbach, Andrea D. Transou, Ian Y. Lee, Tobias Walbert, James Snyder, Anna Lasorella, Ana Valeria Castro, Antonio Iavarone, Houtan Noushmehr

The paper integrates single-nucleus RNA and ATAC sequencing to identify cellular states and regulatory networks associated with the G-CIMP epigenomic transition in IDH-mutant gliomas.

bioRxiv · Jun 9, 2026 · PreprintCancer Biology

The epigenetic evolution of gliomas is determined by their IDH1 mutation status and treatment regimen

Tathiane Maistro Malta, Thaís S. Sabedot, Natalia S. Morosini, Indrani Datta, Luciano Garofano, Wies Vallentgoed, Frederick S. Varn, Kenneth Aldape, Fulvio D’Angelo, Spyridon Bakas, Jill S. Barnholtz‐Sloan, Hui Kong Gan, Mohammad Hasanain, Ann‐Christin Hau, Kevin C. Johnson, , Peter S. LaViolette

This study analyzes the epigenetic evolution of IDH1-mutant and IDH1-wildtype gliomas under treatment, showing IDHmut tumors undergo epigenomic changes resembling IDHwt tumors, with implications for treatment strategies.

Cancer Research · Dec 20, 2023Peer-reviewedGenomics