Thaís S. Sabedot

This paper introduces an age-preserving neuronal iSpheroid platform that models human aging and Alzheimer's disease, revealing disease-associated metabolic changes and potential therapeutic targets.

This study shows that APOE4 impairs lipoprotein secretion in microglia, leading to lysosomal and mitochondrial dysfunction and a proinflammatory phenotype.

The paper shows that PD patients have altered CD4+ T cell responses to fasting/refeeding, leading to impaired neuro-immune signaling through a dysfunctional metabolic program in neurons.

This study identifies RUNX1 and YY1 as master transcription factors modulating neuronal fate and energy metabolism in Alzheimer's disease using patient-derived induced neurons and post-mortem brain data.

This study examines how genomic background and developmental state affect signaling pathways and therapy response in GBM patient-derived cells, finding that differentiation increases TMZ resistance and activates DNA-damage interferon responses.

This study analyzes the epigenetic evolution of IDH1-mutant and IDH1-wildtype gliomas under treatment, showing IDHmut tumors undergo epigenomic changes resembling IDHwt tumors, with implications for treatment strategies.

RGBM identifies transcriptional regulators of glioma subtypes by inferring gene regulatory networks from diverse data sources and outperforming existing methods on benchmark datasets.