Author

Roberto Bottinelli

University of PaviaORCID 0000-0002-4960-7490Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Daniel C. TurneriD· 2 shared Adam Philip SharplesiD· 1 shared Andrea PilottoiD· 1 shared Arianna Votta· 1 shared Beatrice BiferaliiD· 1 shared Beatrice Ciurli· 1 shared Daniele CampolungoiD· 1 shared Danilo MiottiiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersGenetics

Daniel C. TurnerORCID

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Author profile →

2 papers

Recent·Most cited

The interferon-gamma response pathway is a targetable driver of FSHD muscular dystrophy progression

Beatrice Biferali, Federica Del Prete, Mara Salomè, Jose Manuel Garcia Manteiga, Reza Alemohammad, Miriam Mombellardo, Maria Pannese, Emanuele Mocciaro, Francesca Torri, İlker Eren, Elisabetta Ferraro, Dicle Ballikaya, Beatrice Ciurli, Arianna Votta, Daniele Campolungo, , Davide Gabellini

This study identifies the IFN-gamma pathway as a therapeutic target for FSHD by showing its role in driving inflammation and disease progression.

bioRxiv · Oct 19, 2026 · PreprintGenetics

Human skeletal muscle possesses an epigenetic memory of high intensity interval training

Andrea Pilotto, Daniel C. Turner, Emanuela Crea, Raffaele Mazzolari, Lorenza Brocca, Maria Antonietta Pellegrino, Danilo Miotti, Roberto Bottinelli, Adam Philip Sharples, Simone Porcelli

This study shows that human skeletal muscle retains epigenetic memory of high-intensity interval training (HIIT) through hypomethylation and increased gene expression even after detraining.

American Journal of Physiology-Cell Physiology · Nov 21, 2024Peer-reviewedPhysiology