Actin-dependent mechanotransduction controls nucleocytoplasmic partitioning of DNMT3a through ERK1/2 signaling during cutaneous wound healing
Johan Ajnabi, Binita Dam, Ekta Gupta, Tirthankar Saha, Abhik Dutta, Saurav Kumar, Ashish K. Gupta, Dasaradhi Palakodeti, Colin Jamora
The paper shows that actin remodeling during wound healing inactivates ERK1/2, unmasking DNMT3a's nuclear localization signal and enabling its nuclear translocation to regulate epigenetic reprogramming.
bioRxiv · Jan 15, 2026 · PreprintCell Biology