Activated protein C promotes beta-arrestin-2- and c-Src-dependent caveolin-1 (Cav1) phosphorylation and alters Cav1 association with PAR1 and GRK5
Huaping Qin, Lennis B. Orduña-Castillo, Olivia Molinar‐Inglis, Monica L. Gonzalez Ramirez, Miguel Alejandro Lopez‐Ramirez, Carolyne Bardeleben, JoAnn Trejo
This study shows APC activates PAR1 through βarr2 and c-Src to phosphorylate Cav1 and alter its interactions with PAR1 and GRK5 in endothelial cells.
bioRxiv · Nov 2, 2025 · PreprintCell Biology