Author

Lennis B. Orduña-Castillo

University of California San DiegoORCID 0000-0001-7013-861XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:proteomics· 2 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Carolyne Bardeleben· 2 shared Huaping QiniD· 2 shared JoAnn TrejoiD· 2 shared Monica L. Gonzalez RamireziD· 2 shared Cierra A. Birch· 1 shared Irina KufarevaiD· 1 shared Miguel Alejandro Lopez‐RamireziD· 1 shared Olivia Molinar‐InglisiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 30 mutual co-author links

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2 shared papersCell Biology

Carolyne Bardeleben

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2 papers

Recent·Most cited

Cell BiologyCell ReportsPeer-reviewedMar 1, 2026

Signaling bias of the protease-activated receptor-1 is dictated by distinct GRK5 and β-arrestin-2 determinants

Monica L. Gonzalez Ramirez, Lennis B. Orduña-Castillo, Carolyne Bardeleben…·JoAnn Trejo

This study identifies the molecular mechanisms underlying signaling bias in PAR1, showing distinct roles of GRK5 and β-arrestin-2 in thrombin- and APC-induced responses.

4 citationstop 4%

humanproteomics

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Cell BiologybioRxivPreprintNov 2, 2025

Activated protein C promotes beta-arrestin-2- and c-Src-dependent caveolin-1 (Cav1) phosphorylation and alters Cav1 association with PAR1 and GRK5

Huaping Qin, Lennis B. Orduña-Castillo, Olivia Molinar‐Inglis…·JoAnn Trejo

This study shows APC activates PAR1 through βarr2 and c-Src to phosphorylate Cav1 and alter its interactions with PAR1 and GRK5 in endothelial cells.

DOI 10.1101/2025.11.02.686166

humanproteomics

𝕏 PostBluesky