Human MeCP2 binds to promoters and inhibits transcription in an unmethylated S. cerevisiae genome
LeAnn J. Howe, Joshua A.R. Brown, Juan Ausió, Maggie Y.M. Ling
The paper shows MeCP2 binds to yeast promoters and inhibits transcription without DNA methylation or mammalian corepressors, and some Rett syndrome mutations reduce its toxicity.
bioRxiv · Aug 12, 2024 · PreprintMolecular Biology