Stephen J. W. Busby

The paper reports genome sequences of ten multidrug-resistant Escherichia coli strains from Egyptian children with diarrhoea, identifying resistance genes and high-risk clones.

This study maps CRP binding sites in EAEC to reveal its role in regulating virulence genes linked to nutritional state.

The paper sequences two ancestral E. coli K-12 strains to reveal genetic changes from lab-based evolution, questioning their suitability as model organisms.

The paper introduces DNA barcodes for analyzing complex genomic mixtures, enabling identification of specific DNA molecules, strain typing, and virus detection in human genomic backgrounds.

The paper expands RegulonDB to integrate high-throughput binding data with existing knowledge on gene regulation in E. coli K-12, enhancing its comprehensiveness and utility.