Pharmacology & ToxicologybioRxivPreprint
Matrix metalloproteinases proteolyze RAB proteins and contribute to cisplatin-induced ototoxicity
Zahra Zandi, Bridgette Hartley, Wesam Bassiouni…·Amit P. Bhavsar
This study shows MMP-2 and MMP-9 contribute to cisplatin-induced ototoxicity by cleaving RAB proteins, and inhibiting them improves hair cell survival.
DOI 10.64898/2026.02.28.708770