Author

Bridgette Hartley

University of AlbertaORCID 0000-0002-9883-952XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Organism:E. coli· 1 Organism:mouse· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Olivier JulieniD· 2 shared Amit P. BhavsariD· 1 shared Elena I ArutyunovaiD· 1 shared Eytan WineiD· 1 shared Heather ArmstrongiD· 1 shared Howard S. YoungiD· 1 shared Hyunjae Chung· 1 shared Jimmy LuiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersPharmacology & Toxicology

Olivier JulienORCID

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2 papers

Recent·Most cited

Matrix metalloproteinases proteolyze RAB proteins and contribute to cisplatin-induced ototoxicity

Zahra Zandi, Bridgette Hartley, Wesam Bassiouni, Michèle G. DuVal, Shu Luo, Maria J. Spavor, W. Ted Allison, Olivier Julien, Richard Schulz, Amit P. Bhavsar

This study shows MMP-2 and MMP-9 contribute to cisplatin-induced ototoxicity by cleaving RAB proteins, and inhibiting them improves hair cell survival.

bioRxiv · Mar 3, 2026 · PreprintPharmacology & Toxicology

Mechanistic insight into the regulation of virulence factor type 1 pili in pathogenic E. coli by rhomboid protease GlpG

Jimmy Lu, Elena I Arutyunova, Bridgette Hartley, Jonas Wong, Hyunjae Chung, Lanny Buchan, Heather Armstrong, Sadhna Phanse, Howard S. Young, Eytan Wine, Mohan Babu, Justin Chun, Wael Elhenawy, Olivier Julien, M. Joanne Lemieux

This study shows GlpG protease is essential for type 1 pili assembly in E. coli, affecting biofilm formation and bacterial fitness.

bioRxiv · Sep 9, 2025 · PreprintBiochemistry