Matrix metalloproteinases proteolyze RAB proteins and contribute to cisplatin-induced ototoxicity
Zahra Zandi, Bridgette Hartley, Wesam Bassiouni, Michèle G. DuVal, Shu Luo, Maria J. Spavor, W. Ted Allison, Olivier Julien, Richard Schulz, Amit P. Bhavsar
This study shows MMP-2 and MMP-9 contribute to cisplatin-induced ototoxicity by cleaving RAB proteins, and inhibiting them improves hair cell survival.
bioRxiv · Mar 3, 2026 · PreprintPharmacology & Toxicology