Aaron Embry

Bacterial and human exonucleases mediate interkingdom antiviral immunity

This study identifies ISG20 and its bacterial homologs as interkingdom antiviral factors that restrict both bacterial RNA phages and human RNA viruses through UTR trimming.

Bacterial Effector Screening Reveals RNF214 as a Virus Restriction Factor in Mammals

This study identifies RNF214 as a mammalian antiviral factor using bacterial effectors, showing its role in restricting arbovirus infection through ubiquitination-mediated degradation.

Activation and Evasion of the FEAR Pathway by RNA Viruses

This study shows RNA viruses, like DNA viruses, are restricted by the FEAR pathway and have evolved distinct mechanisms to counteract it by targeting SUMOylated Spt16 proteins.