An Arrayed Genome-Wide Perturbation Screen Identifies the Ribonucleoprotein hnRNP K As Rate-Limiting for Prion Propagation
Merve Avar, Daniel Heinzer, Alana M. Thackray, Yingjun Liu, Marián Hruška-Plocháň, Stefano Sellitto, Elke Schaper, Daniel Pease, Jiang‐An Yin, Asvin KK Lakkaraju, Marc Emmenegger, Marco Losa, Andra Chincisan, Simone Hornemann, Magdalini Polymenidou, , Adriano Aguzzi
The paper identifies Hnrnpk as a key regulator of prion propagation through a genome-wide RNAi screen using the QUIPPER assay, showing PSA's ability to reduce prion levels and toxicity in multiple models.
The EMBO Journal · Oct 18, 2022Peer-reviewedNeuroscience