Yingjun Liu

This study shows NG2 glia reduce prion-induced neurodegeneration by inhibiting PGE2 signaling, which promotes microglial activation and neurotoxicity.

The paper identifies Hnrnpk as a key regulator of prion propagation through a genome-wide RNAi screen using the QUIPPER assay, showing PSA's ability to reduce prion levels and toxicity in multiple models.

This study develops an ex vivo mouse brain slice model that mimics brain aging and shows prions accelerate aging-related molecular changes.

This study shows NG2 glia are essential for maintaining microglia homeostasis and presents a method to deplete NG2 glia in vitro and in vivo.

This study shows that SARM1 deficiency accelerates prion disease progression by upregulating XAF1, leading to increased neuronal apoptosis.

This study finds that Lag3 expression increases in prion infections but does not affect disease progression in knockout mice.