Matteo Jacopo Marzi

The paper maps RNA-DNA interactions in 16 human cell types, showing cell-type-specific and dynamic networks that correlate with gene regulation and disease traits.

The paper introduces an IVT-based method with dRNA-seq to detect RNA modifications across the transcriptome, identifying 26,619 modification sites and revealing non-random co-occurrence and isoform-specific patterns.

The paper uses single-cell multi-omic lineage tracing to identify transcriptional, epigenetic, and genetic factors that predict cancer evolution and drug tolerance.

This study shows that chronic stress in male mice reduces sperm miR-34c levels through astrocyte-derived exosomes, leading to transgenerational anxiety and reduced sociability in offspring.